The UK charity for Waldenstrom’s macroglobulinaemia – a rare type of blood cancer
Support Line: 0300 373 8500

Related Conditions

WM can cause a number of other conditions to develop, some of which are more common, and some which are very rare.

Man with Waldenstrom's macroglobulinaemia

The symptoms vary for each condition and will also be different for every individual. It’s important to let your healthcare team know about any symptoms you have, so they can investigate.

These conditions include:

Booklet about Understanding Related Conditions and Symptoms of Waldenström’s Macroglobulinaemia

Related Conditions Booklet

Download or order our Related Conditions Guide to get a complete overview of the symptoms, diagnosis and treatment support provided for conditions related to WM.

Hyperviscosity Syndrome (HVS)

If your WM cells make too much IgM antibody, it can make your blood thicker and stickier than normal. You should contact your healthcare team if you have symptoms.

Cold agglutinin disease (CAD)

This rare condition occurs when abnormal IgM antibodies make red blood cells stick together. This is called agglutination and it usually happens when your body gets cold.

Peripheral Neuropathy (PN)

It is common for people with WM to have damage to the nerves in the arms and legs – the peripheral nervous system. This damage is known as peripheral neuropathy (PN).

Cryoglobulinaemia

Cryoglobulinaemia (cryo ) is a rare condition where abnormal antibodies called cryoglobulins stick together and block blood flow around your body when you get cold.

Amyloidosis

Amyloidosis is a rare condition caused when a protein called amyloid builds up in your body and stops major organs, including the heart and liver, from working properly.

Bing Neel Syndrome (BNS)

BNS is a very rare condition which occurs when the abnormal white blood cells (B-cells) get into the nervous system and affect the brain or spinal cord.

Monoclonal gammopathy of undetermined significance (MGUS)

This is a blood condition that affects cells in your bone marrow. While it isn’t cancerous or harmful by itself a small number of people diagnosed with it go on to develop blood cancer.

When WM transforms

In rare cases, Waldenstrom’s macroglobulinaemia can transform into a faster growing from of lymphoma. If your healthcare team suspect this, they’ll conduct additional tests.